Pete Dumond, Chief Make-up Artist for 25 years at American International Studios, is pink-slipped by the new management from the East, Jeffrey Clayton and John Nixon, who plan to make musicals and comedies instead of the horror pictures for which Pete has created his remarkable monster make-ups and made the studio famous. In retaliaton, Pete vows to use the very monsters these men have rejected to destroy them. By mixing a numbing ingredient into his foundation cream and persuading the young actors that their careers are through unless they place themselves in his power, he hypnotizes both Larry Drake and Tony Mantell, who are playing THE TEENAGE WEREWOLF and TEENAGE FRANKENSTEIN in the picture “WEREWOLF MEETS FRANKENSTEIN” currently shooting on the lot. Through hypnosis, Pete causes Larry in werewolf make-up to kill Nixon in the studio projection room, and later he wills the unknowing Tony to wait for Clayton in his garage at night and brutally choke him to death. Studio guard Monahan, a self-styled detective, stops in at the Make-up Room on his rounds one evening and shows Pete and Rivero–Pete’s reluctant assistant and accomplice–his little black book in which he has jotted down many facts such as the late time Pete and Rivero checked out the night of the first murder. By this show of initiative he plans to get a promotion. Apprehensive, Pete, made up as a terrifying primitive monster, one of his own creations, kills Monahan in the studio commissary at a later point on his beat.

Richards, the older guard sees and hears nothing until he uncovers Monahan’s body. Police investigators uncover two clues: a maid, Millie describes the Monster Frankenstein (Tony, in make-up) who struck her down as he fled from Clayton’s murder, and the Police Laboratory Technician discovers a peculiar ingredient in the make-up left on Clayton’s fingers from his death struggle with Tony. The formula matches bits found in Pete’s old Make-up Room, and the Police head for Pete’s house — where Pete has taken Rivero, Tony and Larry for a grim farewell party to his home which is a museum of all the monsters that he has created in the 25 years in the studio. Pete has stabbed Rivero to death secretly in the kitchen and hidden his body. Finding Tony and Larry trying to escape the locked living room, he attacks them with a knife, but Larry knocks over a candelabra, setting the living room on fire and Pete is burned to death trying to save the lifelike heads of his monster “children” mounted on the wall. The Police break through the door before the flames reach the boys.

Landon’s character is Tony Rivers, a disturbed, angry young man in the James Dean Rebel Without a Cause tradition, seeks hypnotherapy for his problem. Unfortunately, the practitioner he seeks out, played by Bissell, is also a very disturbed man with definite mad scientist overtones, who successfully regresses his patient into a werewolf with tragic results. He is under the belief that man, instead of moving forward, must go back to their pre-evolution states (for some reason, a werewolf). Tony, meanwhile, knows nothing of this. Tony transforms in the high school gymnasium (after he is startled by the school bell suddenly ringing close to him) and kills a girl who is there practicing gymnastics. Realizing that something is wrong, Rivers goes back to the doctor for help. The doctor hypnotizes him again, making him turn back into a werewolf. As he and his assistant, Hugo, prepare to take pictures of this achievement, the telephone rings, which wakes up Rivers and causes him to kill both the doctor and Hugo. He is then shot by the police as he runs from the doctor’s building.